PANETH AND GOBLET CELL RENEWAL IN MOUSE DUODENAL CRYPTS
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چکیده
منابع مشابه
Paneth and Goblet Cell Renewal in Mouse Duodenal Crypts
Proliferation of Paneth and goblet cells of mouse duodenal crypts was studied by high resolution light microscope radioautography. In one group of mice, blood levels of thymidine-(3)H were sustained for up to 12 hr by repeated injections of isotope to facilitate identification of proliferating cells. In these animals, many goblet cell nuclei incorporated thymidine-(3)H whereas only 1 of 6261 ta...
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Nutritional and genetic risk factors for intestinal tumors are additive on mouse tumor phenotype, establishing that diet and genetic factors impact risk by distinct combinatorial mechanisms. In a mouse model of dietary-induced sporadic small and large intestinal cancer in WT mice in which tumor etiology, lag, incidence, and frequency reflect >90% of intestinal cancer in Western societies, dieta...
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Wnt signaling, transduced through β-catenin/Tcf4, maintains the undifferentiated state of intestinal crypt progenitor cells. Mutational activation of the pathway initiates the adenoma-carcinoma sequence. While all other differentiated epithelial cells migrate from the crypt onto the villus, Paneth cells home towards the source of Wnt signals, i.e. the crypt bottom. We find that expression of a ...
متن کاملPaneth Cell Granule of Mouse Intestine
The Paneth cell secretion of the mouse intestine has been reported to be an acid mucopolysaccharide-protein complex; tryptophan as well as alpha acylamido carboxyl, amino, and phenolic groups of protein have been localized to the characteristic granules by means of histochemical staining procedures (13). Sulfhydryl and disulfide groups of protein have also been localized to the granule (14). Th...
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The Lkb1 tumour suppressor is a multitasking kinase participating in a range of physiological processes. We have determined the impact of Lkb1 deficiency on intestinal homeostasis, particularly focussing on secretory cell differentiation and development since we observe strong expression of Lkb1 in normal small intestine Paneth and goblet cells. We crossed mice bearing an Lkb1 allele flanked wi...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1969
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.41.1.251